The old WoD collection is so immense and since I have all the books I disagree that the Storyteller systems is heavily tied to the setting. I have used the system to run all manner of other settings. The system is ideal for running anything non-supernatural, simply remove the powers. If you want a bit of supernatural then simply plug a few powers back in.
Since I also have Exalted, Trinity Univerese and Street Fighter it is easy to too take rules from those settings and add to a new setting. Most importantly since White Wolf themselves have used the Storyteller system for several very different settings that proves the system can be used
I am playtesting REIGN at the moment, but since I have signed a non-disclosure agreement I cannot discuss details about REIGN. From Greg's writeup "So I turned the ORE to a fantasy setting I’d been contemplating for years" shows that the ORE system can be adapted.